Transforming Growth Factor-beta Type I Receptor

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE II TGF-BETA RECEPTORS to bind TGF-BETA and regulate a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Also Known As:

Receptor, Transforming Growth Factor-beta Type I; Activin Receptor-like Kinase 5; Receptor, TGF-beta Type I; Serine-Threonine-Protein Kinase Receptor R4; TGF-beta RPK; TGF-beta Receptor Protein Kinase; TGF-beta Type I Receptor; TGF-beta Type I Receptors; TGFBR1; TbetaR-I Kinase; Transforming Growth Factor beta Receptor I; Transforming Growth Factor, beta Receptor 1; Type I TGF-beta Receptor; Type I TGF-beta Receptors; Activin Receptor like Kinase 5; Kinase, TbetaR-I; Serine Threonine Protein Kinase Receptor R4; TGF beta Receptor Protein Kinase; TGF beta Type I Receptor; TGF beta Type I Receptors; TbetaR I Kinase; Type I TGF beta Receptor; Type I TGF beta Receptors

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Transforming Growth Factor-beta Type I Receptor: 565
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Transforming Growth Factor beta Receptors: 836
        Transforming Growth Factor-beta Type I Receptor: 565
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Transforming Growth Factor beta Receptors: 836
        Transforming Growth Factor-beta Type I Receptor: 565
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Transforming Growth Factor-beta Type I Receptor: 565

J-A Moon Selected Research

J-A Moon Research Topics

Disease

Drug/Important Bio-Agent (IBA)